Since 1994, the Center for Translational Data Science has hosted a booth at the annual SuperComputing Conference, though we have been present at the conference since 1992. The SC Conference Series is an annual international conference for high performance computing, networking, storage, and analysis. This year, the conference was both virtual and in-person in St. Louis, Missouri. Watch below as our Director, Bob Grossman, describes building data commons and data ecosystems using open source Gen3 software at SC21. This application helps make data readily available to the scientific community to improve patient outcomes and accelerate scientific discovery.